Global Medical Discovery features paper: Low-density lipoprotein transport through an arterial wall under hyperthermia and hypertension conditions–An analytical solution

About The Author

Professor Kambiz Vafai received his B.S. in Mechanical Engineering from the University of Minnesota at Minneapolis in 1975. He received his M.S. degree in Mechanical Engineering from the University of California at Berkeley in 1977 and his Ph.D. degree in Mechanical Engineering also from the University of California, Berkeley in 1980. He is currently serves as Distinguished Professor of Mechanical Engineering at the University of California, Riverside, USA.

Professor Vafai holds 12 US patents associated with electronic cooling and medical applications. His research interests include transport through porous media, multiphase transport, aircraft brakes, biomedical applications, microcantilever-based biosensors, biofilms, electronic cooling, macromolecule transport through arteries, cooling enhancement investigations, modeling of tissue and organs, natural convection in complex configurations, analysis of porous insulations, heat flux applications, free surface flows, flat-shaped heat pipes, thermal design and modeling, and feasibility, optimization, and parametric studies for various engineering applications and power electronics. He is one of the highest cited in his fields of research.

He is currently Editor in Chief- Journal of Porous Media and Editor in Chief- Special Topics & Reviews in Porous Media

Journal Reference

J Biomech. 2016;49(2):193-204.

Iasiello M¹, Vafai K², Andreozzi A³, Bianco N³.

Show Affiliations

1. Department of Mechanical Engineering, University of California, Riverside, CA 92521, USA; Dipartimento di Ingegneria Industriale, Università degli Studi di Napoli Federico II, P.le Tecchio, 80, Napoli 80125, Italy.
2. Department of Mechanical Engineering, University of California, Riverside, CA 92521, USA. Electronic address: vafai@engr.ucr.edu.
3. Dipartimento di Ingegneria Industriale, Università degli Studi di Napoli Federico II, P.le Tecchio, 80, Napoli 80125, Italy. 

Abstract

An analytical solution for Low-Density Lipoprotein transport through an  arterial wall  under hyperthermia conditions is established in this work. A four-layer model is used to characterize the arterial wall. Transport governing equations are obtained as a combination between Staverman-Kedem-Katchalsky membrane equations and volume-averaged porous media equations. Temperature and solute transport fields are coupled by means of Ludwig-Soret effect.

Results are in excellent agreement with numerical and analytical literature data  under  isothermal conditions, and with numerical literature data for the hyperthermia case. Effects of hypertension  combined with hyperthermia, are also analyzed in this work.

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